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Canada Goose Canada Goose Parka Parka Tendayi succumbed to African trypanosomiasis, known as African sleeping sickness. It occurs primarily in the DRC, and is far more alarming than its name would suggest.The parasitic disease is transmitted by the tsetse fly and attacks the central nervous system. It can cause people to sleep all day and stay up through the night. The illness can also lead to severe hallucinations some patients have been known to chase neighbors with machetes and scream in response to the slightest touch. And it can be deadlywhen not treated properly.The number of recorded cases hit a seemingly manageable numberlast year fewer than 3,000, according to the World Health Organization and the treatments available today are far superior canada goose store to what Tendayi was given. But Mutombo remains only cautiously optimistic.Because the illness affects buy canada goose jacket cheap such a canada goose small and isolated population, there isn’t that much interest globally or even within the DRC in addressing it.Mutombo, who studied medicine at the University of Bujimayi in the DRC, said about one page in his infectious diseases textbook was devoted to sleeping sickness.After graduating in 2004, many of Mutombo’s peers migrated to big cities in South Africa to make a reasonable income.Mutombo was the sole medical doctor, and there were three nurses on staff.The fresh faced physician functioned as the hospital’s pediatrician, gynecologist and infectious disease specialist essentially, he took on every case that came his way.The work, especially with its low pay, was a “sacrifice,” the father of three told The Huffington Post.Until 2009, a medication called melarsoprol which a Swedish pathologist developed in 1949 was the only feasible treatment for a patient with stage two sleeping sickness. About 1 in 20 people die after taking the arsenic based treatment, and it causes such severe pain that it has been dubbed Canada Goose sale “fire in the veins.” It wasn’t all that effective, either: About 40 percent of people relapsed, according to Mutombo.”It’s terrible,” Mutombo said of watching his patients take the medication and endure agony and fear.He was 39 years old in July 2005, when Canada Goose online he was diagnosed with stage two sleeping sickness meaning the parasite had already infected his central nervous system. Patients at this buy canada goose jacket stage can experience severe issues including personality changes, sleep disturbances and partial paralysis.Tendayi was treated with melarsoprol for 20 days. He relapsed six months later and returned for another round of treatment. When Tendayi relapsed again in 2007, he was “disappointed,” Mutombo said.That’s when he stopped coming in for treatment. When left untreated, sleeping sickness will eventually lead to coma and death, according to the Centers for Disease Control and Prevention.”It was complicated,” Mutombo said of the case. “All these years later I have his name in my mind. I still look at his picture.”Because stage one symptoms http://www.canadagoosecanadaoutlet.com such as cheap Canada Goose headache and fever are associated with a number of other conditions, many Canada Goose Jackets patients don’t seek treatment until they’ve reached stage two, Mutombo said. People often assume they have malaria and spend months getting treatment for that.It’s when patients start sleeping all day and staying up all night, when they can’t stop smiling or feel overwhelmingly angry, when they can’t eat and start losing weight that’s when they’ll realize they likely have sleeping sickness, Mutombo said. But by that point, they’ve already reached canada goose clearance sale stage two.Mutombo felt helpless after another patient who had been treated with melarsoprol died. canada goose outlet Canada Goose Outlet He thought he wouldn’t be able to find help in improving the course of treatment.That changed more quickly than Mutombo could ever have expected.In 2006, he learned that the nonprofit Drugs for Neglected Diseases Initiative (DNDi) was looking for researchers to conduct clinical trials and explore alternative treatments for sleeping sickness. Mutombo pounced on the opportunity. (HuffPost is currently raising money to support DNDi’s efforts to identify new drugs that are easy to administer.)DNDi, which develops drugs and treatments for overlooked illnesses, hired Mutombo as a local investigator.For the next three years, Mutombo immersed himself in research. He spent six months doing a clinical internship with Sanofis Aventis, a France based pharmaceutical company. He also spent half a year working in Geneva completing a fellowship with the World Health Organization.Along with Doctors Without Borders and other partners, DNDi made a breakthrough in 2009: A treatment called nifurtimox eflornithine combination therapy(NECT), which had a cure rate of more than 96 percent, was approved for people with stage two sleeping sickness. Unlike another viable treatment that has been used in recent years, patients only need to receive14 infusions over a period of a week together with a 10 day pill regimen.It was a great step forward in treating the sleeping sickness, but its application came with a few challenges.Patients have to undergo a spinal tap to determine where they are on the disease spectrum and how much medicine they need, and canada goose deals hospitals need staff members who are well versed in administering the treatments. Clean needles aren’t easy to come by. The equipment is bulky and difficult to transport.Patients also have to stay canada goose coats at a hospital for the duration of the treatment. For people living in rural areas, especially now that the country is on the brink of a civil war, it can take hours or even days to get to a clinic if they can get there at all.That’s why Mutombo and other researchers involved with DNDi are eager to keep working toward developing an oral pill to eliminate most of the challenges NECT presents Canada Goose canada goose clearance Parka.